SG Weightloss

Mounjaro for PCOS and Insulin Resistance: Does It Work?

Mounjaro for PCOS

Polycystic Ovary Syndrome (PCOS) is a disorder that occurs in 1 out of 10 women of the reproductive age around the world and is closely linked to insulin resistance, weight gain, and hormonal disbalance. PCOS management is a complicated process to many, which involves diet, lifestyle change, and drugs. Such medications as Mounjaro (tirzepatide) have recently been in focus, not only for type 2 diabetes and weight loss but also due to the possible application in the case of PCOS-related insulin resistance. However, is Mounjaro effective in PCOS? Let’s break it down.

What Is Mounjaro?

Mounjaro (tirzepatide) is a medication that is injected once a week and was initially used as treatment of type 2 diabetes. It acts by imitating two important intestinal hormones GLP-1 and GIP that assist in keeping blood sugar levels normal, decrease the appetite, and give a sense of fullness. This two-fold process provides it with a competitive advantage in comparison to the old GLP-1 drugs such as Ozempic.

Mounjaro is used off-label to lose weight in 2023 and beyond and it is beginning to gain popularity with women with PCOS, particularly those who are insulin resistant and obese.

The role of Mounjaro in PCOS and Insulin resistance

A fundamental issue of PCOS is insulin resistance. Elevated levels of insulin stimulate enhanced production of androgen (male hormone) thereby causing acne, abnormal periods and ovarian cysts. Also, insulin resistance renders weight loss highly challenging- a significant challenge to most women with PCOS.

Mounjaro addresses insulin resistance in several ways:

  • Enhances insulin sensitivity

Mounjaro has the potential to reduce the insulin levels in the body, thereby lowering the hormonal imbalance that is characteristic of PCOS by increasing the sensitivity of the body to insulin.

  • Helps one lose weight in large amounts

Clinical trials include weight loss of 15-20 percent of the total body weight with tirzepatide. This is important to PCOS, because a 5-10 percent weight loss is capable of making a huge difference in symptoms.

May control menstrual periods

There is some anecdotal evidence and preliminary research that restoring insulin balance is able to normalize ovulation and menstrual cycles however further studies are required to determine the direct effect of Mounjaro.

What the Research Says

Although not yet officially approved, Mounjaro is being investigated in a number of small studies and current clinical trials in the field of PCOS treatment. Early findings show promise:

  • In a 2024 study, tirzepatide significantly increased insulin sensitivity and weight reduction in PCOS women during 24 weeks.
  • The subjects also experienced improved energy levels, decrease in sugar cravings and increased periods.

Nevertheless, there are still long-term studies being undertaken to confirm these advantages, as well as to be safe in non-diabetic population.

Availability in Singapore

In case you are in Singapore and you are thinking of using Mounjaro in relation to PCOS associated weight and insulin resistance, here are the facts that you need to know about this drug:

  • A number of clinics are now offering Mounjaro weight loss Singapore as a trending topic that is now medically supervised to treat obesity and metabolic problems.
  • General: In 2025, Mounjaro injection Singapore received the approval of the Health Sciences Authority (HSA) to use in the treatment of type 2 diabetes and weight management.
  • Off-label, doctors can use Tirzepatide to treat weight loss Singapore in PCOS patients that fit the requirements (e.g., high BMI and comorbidities such as insulin resistance).
  • Be very careful when making on-line purchases- when you are typing in things like Buy Mounjaro online Singapore ensure that the source of purchase is a licensed pharmacy. Do not use grey-market websites that are selling without a prescription.

Risks and Side Effects

Mounjaro, similar to other agonists of GLP-1 receptors, may produce side effects, in particular during the initial weeks:

  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue

The majority of the side effects are non-dangerous and disappear with time. Nevertheless, under the guidance of a doctor, it is important to begin in order to reduce the risks.

Mounjaro for PCOS(1)

Do You think Mounjaro should be used to treat PCOS?

Mounjaro has the potential to become a game changer in women with PCOS who failed to respond to the traditional interventions. Its strong insulin sensitivity and weight loss properties are potentially potent off-label agents particularly in Singapore, where these activities are being allowed by the regulatory authorities.

However, it’s not for everyone. A proper medical examination will be required, and safety information in PCOS patients over time is yet to be established.

Conclusion

For women battling PCOS and insulin resistance, Mounjaro injection Singapore offers a promising tool—especially when paired with lifestyle changes. Whether you’re trying to lose weight, regulate your cycles, or improve insulin function, Tirzepatide for weight loss Singapore is worth discussing with your doctor.

Just remember—if you’re looking to Buy Mounjaro Online Singapore, always go through licensed providers to ensure safety, legality, and authenticity.

If you’re considering Mounjaro or other weight loss treatments, it’s important to seek professional advice to ensure safe and effective results. For expert in-clinic consultations, visit Nexus Clinic. Alternatively, you can access licensed medical advice and conveniently purchase prescribed medications online through DoctorOnCall and their Official Pharmacy.

FAQs

What is Mounjaro used for?

Mounjaro is a prescription medication approved for managing type 2 diabetes. It is also widely studied and used off-label for weight management.

Mounjaro is a dual GIP and GLP-1 receptor agonist. It helps regulate blood sugar, increase insulin release, and suppress appetite—leading to improved weight loss compared to some other medications.

Mounjaro is injected once weekly, on the same day each week, at any time of day— with or without food.

Nausea, diarrhea, decreased appetite, vomiting, constipation, and stomach pain. Side effects usually become milder over time.

It should not be used by people with a history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or those allergic to tirzepatide. Pregnant and breastfeeding women should avoid use unless advised by a doctor.

Clinical studies suggest that Mounjaro may lead to greater weight loss than Ozempic, but effectiveness varies by individual.

Mounjaro is generally more expensive than Ozempic, starting from several hundred dollars per month depending on dosage. Discounts may apply for bulk or subscription plans.

Yes, all Mounjaro orders are shipped securely in plain packaging for privacy.

Standard shipping takes 3–5 working days, with express options available.

We only supply authentic, pharmacy-dispensed Mounjaro sourced through regulated pharmaceutical channels.

People Also Ask

Is Mounjaro approved for weight loss?

No, Mounjaro does not pass as a weight loss drug. But tirzepatide (its active ingredient) has been used to treat weight loss, as Zepbound. In another GoodRx Health article, you can learn more about the comparison between Zepbound and Wegovy.

Mounjaro and Ozempic are not the same drugs, but they operate in the same manner. Mounjaro is a GIP receptor agonist GLP-1 receptor agonist. Ozempic acts only on GLP-1 . They are both acceptable to reduce blood sugar in individuals with type 2 diabetes besides healthy diet and physical activity.

Weight loss is not immediate and it may take up to 18 months before you see the same results that you are seeking with Mounjaro. After two months, 9 months and four months you can expect to lose 6 percent, 9 percent and 11 percent of your body weight respectively. However at 18 months, Mounjaro patients lose approximately 21% of their weight.

Tirzepatide (Mounjaro®) should not be taken when you are pregnant or are intending to become pregnant, when you are breastfeeding, or you have some health conditions. When taking the contraceptive pill (convincing pill) with tirzepatide (Mounjaro ®), you need to use a second form of contraception like a condom.

These were the most frequently reported side effects of Mounjaro in clinical trials. Some of the possible digestive issues that have been reported with Mounjaro include nausea, diarrhea, constipation and vomiting. Such side effects are not usually severe. Nevertheless, in a few instances, such issues in the digestive system may be acute.

Mounjaro had lost a quarter of the body weight in 32% of compared to 16% on Wegovy. Users of Mounjaro shed 18cm on their waistline on average versus 13cm using Wegovy. Mounjaro users were also seen to have improved blood pressure, blood sugar and cholesterol levels. The side-effects were similar in both.

There are two weight loss drugs which are popular and share side effects such as diarrhea and nausea and occasionally loss of hair. Wegovy or Ozempic is a brand name of Semaglutide that could be associated with increased gastrointestinal problems. Mounjargo is a brand name of tirzepatide, which targets a different hormone and can result in less serious symptoms and fewer frequently.

Summary. The weight gain is typical when you quit GLP-1 weight loss drugs such as Mounjaro, and research indicates that the weight gain of up to 14% is achievable. On discontinuation of Mounjaro, the positive effects are also discontinued. Others report that their appetite is increased and go back to their old diet.

The facial hollowing, sagging, and loss of volume that may result following rapid weight loss and especially when using GLP-1 agonists are called Ozempic Face and Mounjaro Face. These alterations may show the face as older, exhausted or as gaunt, as the body becomes thinner.

The average patient loses 2-4% of body weight (approximately 2-4kg in a 100kg person) within the first month of taking Mounjaro, with individual differences and starting dose. Although this initial loss of weight is an encouraging result, the greatest gains were realized after 3-6 months of maintenance doses.

Which foods do I need to avoid using with Mounjaro?

  • processed or cured meats.
  • butter.
  • full fat dairy products.
  • fried foods.
  • palm oil or coconut oil.

Anxiety can also be a side effect of Mounjaro to some people. Known Mounjaro side effects include mood changes, anxiety and depression. They are unusual but you might have your mood changed when you take the medication. Most individuals can handle any anxiety that they develop when taking Mounjaro.

Some patients who have taken Mounjaro have reported cardiovascular diseases like heart attack and stroke. A heart attack can cause symptoms such as chest pains, shortness of breath and nausea. A stroke has such symptoms as feeling numb, confused, and unable to speak or comprehend speech.

Mounjaro is costlier than Ozempic. As of early 2024, the uninsured price of Ozempic was approximately 935 a month in the U.S. Mounjaro cost 1069 per fill, the Eli Lilly website stated. It is reported that the drug is as much as $1,267.

Consumption of alcohol with Mounjaro does not reduce its effectiveness but it may increase the difficulty of weight reduction. Mounjaro is likely to enhance the side effects when consumed with alcohol. Alcohol consumption may raise the blood sugar level and intensify Mounjaro side effects or exacerbate diabetes symptoms.

Yes, Mounjaro (tirzepatide) is an aid in burning fat by imitating natural hormones that control the appetite and metabolism resulting in reduced food craving, premature fullness, and better fat storage and breakdown (lipolysis). It also inhibits the development of new fat cells (lipogenesis), and it provides an optimal environment to maintain fat loss, and in studies it has been shown that visceral fat reduces greatly.

The PI of Mounjaro has a boxed warning about the risk of thyroid C-cell tumors. Mounjaro should not be used in patients who have a personal or family history of MTC or in patients with MEN 2.

It might not be important to take Mounjaro in the night or in the morning, then. Mounjaro is most conveniently injected in the time of the day that you find most suitable. It ought to be the period at which you are most likely to remember your dose and inject the medicine properly.

Tirzepatide (Mounjaro or Zepbound)

Numerous researches indicate that it is among the most effective drugs in its category. Tirzepatide is a combination of GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. The twofold effect assists in controlling the levels of sugar in the blood, burning fats, and suppressing the desire to eat.

Whereas you may lose weight with 2.5 mg dose of Mounjaro, the drug will be effective to a large extent provided that you titrate once or twice to initial maintenance strength. It is very uncommon to have a clinician who will be willing to keep you at the baseline level.

The effects of Mounjaro are more effective in reducing A1C than those of Ozempic.

Individuals receiving any amount of Mounjaro experienced a higher decrease in hemoglobin A1C (HbA1C or A1C) than those who were receiving Ozempic. A1C is the average levels of your blood glucose levels in 3 months. Mounjaro might be a good option in case you require further assistance with reducing your A1C.

Does Ozempic, Wegovy, Mounjaro or Zepbound make people lose hair? These medicines have been reported to cause hair loss following rapid weight loss, but this does not seem like a permanent or widespread side effect. Not all persons will have their hair fall out with Ozempic, Wegovy, Mounjaro or Zepbound.

The sensation of disease is occasionally accompanied by vomiting (being sick). The reason behind this is because of the mechanism of action of Mounjaro weight loss injections which is to fill your tummy. And in fact, this is one of the mechanisms by which the medicine works to help you lose weight, when you are full and satisfied, you will eat less.

Which is the alternative to Mounjaro? Wegovy (semaglutide) is now the most promising alternative of Mounjaro and it is particularly effective in the case of a combination with extensive support. The studies of Second Nature indicate that Wegovy has a potential weight loss of 19.1 percent with proper support, which is close to 20.2 percent shown by Mounjaro in clinical trials.

Although people have different experiences, one of the safe and sustainable weight loss ranges is 1 pound and 2.5 pound per week. That will be approximately 4 to 10 pounds within the first 4 weeks. There are those who can experience poorer tolerance especially at higher doses or by combining with other lifestyle modifications such as a low-calorie diet and increased activity.

You might be a candidate if:

  • Your BMI is 30 or more (that is considered obesity).
  • at least one weight-related condition including: High blood pressure. High cholesterol. Sleep apnea. Fatty liver disease. Polycystic ovary syndrome (PCOS) Joint disturbances involving overweight.

And in case you are tired or sluggish you are not alone. One of the frequent Mounjaro side effects, with a range of one in 10 to one in 100 patients, is fatigue. Since it is a relatively new drug, we do not as yet understand why Mounjaro makes people feel tired. Nonetheless, it has a number of potential reasons.

Mounjaro does not make your face old, no. The alterations in your face which occur as you take medications such as Ozempic, Wegovy or Mounjaro are not the effect of the medication but because of the rapid loss of weight.

Even though GLP-1s are popularly prescribed to aid in the management of diabetes and weight loss, recently, there have been reports of a side effect called Ozempic teeth. The mentioned symptoms, including dry mouth and more pathological gum and dental problems, seem to be more or less grounded in dehydration and decreased saliva levels.

You can lose a lot of weight in the early stages- this is probably water loss as you burn off stored carbohydrates (glycogen) to give energy. Your body stores 3g of water per 1g of carbohydrates that you store.

When you raise your dose faster than your body can adjust to, you may have undesirable Mounjaro side effects. Potential side effects such as nausea, sickness and diarrhoea are not uncommon when increasing your dose, particularly when you do so too quickly.

It may take you 12 weeks of treatment to lose as much as 8% of your body weight.

One to two cups of black coffee are safe when you take Mounjaro, however, they may intensify certain side effects, mask others, or increase your blood sugar, which opposes the effect of the drug.

Yes, eggs can be a great food to consume when taking Mounjaro. They are a low-calorie protein that stabilizes your blood sugar levels, lean, and builds muscle, which can boost your weight loss.

8 weight loss tips with Mounjaro.

Take your medicine as you were told.

  • Take your medication as prescribed.
  • Follow a balanced diet.
  • Do regular exercise.
  • Stay hydrated.
  • Get enough sleep.
  • Practice stress management styles.
  • Address common side effects.
  • Rotate injection sites.

Ozempic Face and Mounjaro Face are the terms used to describe the process of hollowing, sagging and loss of facial volume that may happen due to a sudden weight loss and specifically when using GLP-1 agonists. The face may be older, weary or gaunt, although the body becomes thinner.

Do not use tirzepatide (Mounjaro) when you are pregnant or when you plan to become pregnant, or when you are breastfeeding, and also not on the condition of some ailments. When you are taking tirzepatide (Mounjaro 2) and the birth control pill, then an extra method of birth control, like a condom, should be used.

Mounjaro had a lower risk of cardiovascular death, heart attack, or stroke than Trulicity, by 8 percentage points (hazard ratio: 0.92; 95.3% CI: 0.83 to 1.01), and passed the prespecified non-inferiority criteria ( upper limit of 95.3% CI of the hazard ratio < 1.05).

Yes, Mounjaro is connected with the temporary loss of hair, although, it is rather connected with the rapid loss of weight and deficiencies of nutrients which appear when using this medication, as opposed to the direct influence of the drug on the hair. This condition is referred to as telogen effluvium and normally begins a few months following the cause and is interim, hair growing back usually resumes as the body adapts. The best way to fight this is to eat nutritious, seek specific recommendations with your health care provider, and to focus on any underlying stress or nutritional deficiencies.

Some long-term Mounjaro side effects are persistent digestive (nausea, vomiting, diarrhea, constipation), possible kidney problems caused by dehydration as a result of frequent vomiting or diarrhea, and the possibility of acute pancreatitis or gallbladder complications such as gallstones. Another possible long-term risk that is rather infrequent is thyroid cancer. Although several side effects are short-term, severe ones such as pancreatitis may cause permanent health complications and thus need long-term management, therefore, it is essential to see a doctor when you experience severe or persistent side effects.

The prescribing information of Mounjaro cautions against the severe gastrointestinal disease, whereas the prescribing information of Ozempic does not. In clinical studies, a greater proportion of individuals discontinued taking Mounjaro because of gastrointestinal side effects and both drugs had a higher side effects at higher doses.

between $1,000 and $1,200

In the absence of insurance, Mounjaro costs between $1,000 and 1,200 every month, depending on the pharmacy.

Foods that should be avoided when taking Mounjaro.

High Glycaemic Fruits and Vegetables: Pineapple, watermelon, mango, overripe bananas, potatoes and sweetcorn are to be avoided. High Sugar Foods: Avoid sweet, biscuits, cakes and carbonated beverages. These have the ability to interfere with your sugar balance.

Yes, Mounjaro (tirzepatide) assists in burning fat by imitating the body hormones that regulate cravings and metabolism, resulting in fewer cravings to eat, fullness, and fat storage and breakdown (lipolysis). It also decreases the formation of new fat cells (lipogenesis), which forms an optimal environment to maintain fat loss, and research indicates the most remarkable decreases in visceral fat.

Slimming does not occur in a single day and a maximum of 18 months might be required before you achieve the desired effect with Mounjaro. Your body mass will decrease by a factor of 6 percent, 9 percent, and 11 percent in two months, three months and four months respectively. However, with the 18-month mark, Mounjaro patients have an average weight loss of 21%.

Mounjaro does not lose its effectiveness with alcohol consumption, but it can result in more difficult weight loss. Mounjaro is frequently taken along with alcohol and increases the side effects. Alcohol may cause a rise in blood sugar and may cause more adverse effects of Mounjaro or exacerbate diabetes symptoms.

The length of time you take Mounjaro is not limited to a period provided you are still able to tolerate and benefit with the drug. Mounjaro may be taken in the long-term to ensure that you have a healthy body weight. The medical professional attending to you will prescribe you the right dosage to maintain.

Which is the best weight loss prescription drug?

  • Tirzepatide (Zepbound): Maximum weight loss of 22.5 percent.
  • Semaglutide (Wegovy) Up to 14.9% mean weight reduction.
  • Liraglutide (Saxenda): average of 8 percent weight loss.
  • Phentermine-topiramate (Qsymia): 711 percent of weight loss with dose.

Mounjaro can also cause the problem of anxiety to some people as a side effect. The side effects of Mounjaro include mood changes, including anxiety and depression. They are not common, but there is a possibility that your mood will be influenced because of taking the medication. Any anxiety that people feel when taking Mounjaro is manageable to most people.

Though the weight loss with the 2.5 mg dose of Mounjaro is possible, the medication will prove significantly better when you titrate once at least to the initial maintenance strength. And it is very uncommon that a clinician will be willing to maintain you at the initial level.

Related posts:

  1. How to Minimize Ozempic Injection Pain
  2. Wegovy vs Ozempic : What’s the Difference?
  3. Body Positivity and Medical Weight Loss
  4. Ozempic vs Mounjaro vs Wegovy: Which Provides Better for Weight Loss in Malaysia?